Quality in e-learning is connected to innovation, both in the human resources and technological-didactics fields. The evolution of didactics material and teaching methodology must follow the rhythm to which technological tools, students' background and cognitive models change and evolve, always remembering the basic principles of traditional pedagogy. Innovation is considered as the propulsive element determining the structure and the success of the eLearning model itself and from this perspective it is fundamental to re-think the university model, paying more attention to the influence of social and technological changes on the didactic processes. The present volume,“E-Learning Quality Assurance:A Multi-Perspective Approach”, has been conceived in the frame of a wide reflection about quality assurance in e-learning, in the context of institutionalmanagement and organization and services and contents production. All the articles included are the expression and testimony of the experiences of professionals and experts in the field and of particular institutional realities shaped on the basis of national and local standards. All the cases described represent the global effort in trying to propose different interpretations of the concept of quality and to find useful solutions to achieve it. Anna Baldazzi: Expert in Information Sciences and Research Methodology; Professor at Università degli Studi “Guglielmo Marconi”, Rome - Italy; Scientific Coordinator of the FormaMente Review. Laura Ricci: M.A. in Foreign Languages and Literatures;Head of the International Relations Office at Università degli Studi “Guglielmo Marconi”, Rome - Italy. Valentina Valle Baroz:M.A. in Humanities and Journalist; International Relations Officer at Università degli Studi “Guglielmo Marconi”, Rome - Italy.