In this book PNEI paradigm presents itself in its full extension: from the description of the historical and philosophical bases of the paradigm; to the biological revolution underway, which through the bursting of epigenetics radically changes the traditional view of genetics and of the evolution of the human species; from the description of nervous, neuroen¬docrine, immune, psychic systems and their reciprocal influences; to the modulation tools of the human network for preventive and therapeutic uses, such as nutrition, physical activity, psychotherapy, meditation and other behavioural and natural medicine techniques; up to the final part that presents integrated care schemes, proposed on the basis of the available scientific evidence, for acute cardiovascular diseases, disturbances of the psyche-brain system, immune disorders, eating and metabolism disorders, reproductive and sexual dysfunctions and cancer.